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更高效的PEI聚乙烯亚胺聚合物转染试剂

Polyethylenimine HCl MAX, Linear, Mw 40,000

线性化聚乙烯亚胺盐酸盐 MAX（PEI 40，000）

基本描述：

Polyethylenimine HCl MAX, Linear, Mw 40,000（PEI 40，000）是热卖产品线性化聚乙烯亚胺PEI25,000的升级产品，不同之处在于1）完全水解（去乙酰化）；2）PEI25，000的盐酸盐形式，具更高的水溶特性；3）含更长连续性乙烯亚胺（ethyleneimine）片段，其质子化氮水平比PEI25，000提高11%以上。本品经碱中和后，可转化为线性化自由胺（PEI），此时分子量正相当于25,000。

Thomas M，et al（2005）研究数据表明，去乙酰化的PEI 40,000（Polyethylenimine MAX 40,000）体外质粒DNA转染效率提高21倍，小鼠体内靶向效率达到10,000倍，随之肺部特异疗效显示增强1500倍。

PEI MAX 40K is easier to use and offers consistently higher titers than PEI 25K. PEI 25K transfection solutions typically take several hours to prepare, while PEI MAX 40K can be converted to a ready-to-use solution in under two hours. Additionally, PEI 25K contains 4-11% residual propionyl groups, which prevents the polymer backbone from strongly binding to DNA. PEI MAX 40K’s fully depropionylated structure means each batch performs consistently higher.

Comparison of PEI 25K (#23966) and PEI MAX 40K (#24765). 
Method: 10e6/mL HEK293 cells in 50 mL FS transfected with IgG64 plasmid pair. PEI:DNA 4:1. Samples taken 120 hpt. Quantified with Thermo Fisher #23310. N=4 each. Error bar = standard deviation.

A pre-made sterile-filtered solution of PEI MAX 40K is available as our Transporter 5™ Transfection Reagent.