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品牌： | Leading Biology | 货号： | LM14912 |
规格： | 7 ml | 产品官网链接： | |
产品分类： | 单克隆抗体 | 研究领域： | |
产品概述： | At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. āWhen combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).ā | 来源： | Mouse |
靶点/蛋白质： | 特异性： | Human | |
存储温度： | Store at 2 to 8°C.Antibody is stable for 24 months. | 存储溶液： | |
应用： | 参考文献： | McNally, AK. et al. 2011. Exp. Mol. Pathol. 91: 673-681. | Matsuda, A. et al. 2009. Invest. Ophthalmol. Vis. Sci. 50: 2871-2877. | Gulubova, M. et al. 2008. Clin. Exp. Metastasis. 25: 777-785. | Cassaday, RD. et al. 2007. Clin. Cancer Res. 13: 540-549. | | |
详情介绍： | Function Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. Cellular_Location Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts Tissue_Location Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. | ||
别名： | T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, CD1a, CD1A | 说明书： | |
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8000万＋
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