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品牌: | Leading Biology | 货号: | LM14915 |
规格: | 20 μg | 产品官网链接: | |
产品分类: | 单克隆抗体 | 研究领域: | |
产品概述: | At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa).ā | 来源: | Mouse |
靶点/蛋白质: | 特异性: | Human | |
存储温度: | Store at 2 to 8°C.Antibody is stable for 24 months. | 存储溶液: | |
应用: | 参考文献: | van de Rijn M et al. J Immunol 1983, 131(2):851-5 | Lerch PG et al. Hum Immunol 1983, 6(1):13-30 | Knapp W. et al. (eds) Leukocyte Typing IV, p251-263, Oxford University Press, Oxford, 1989 | Khalili-Shirazi A, et al. J Neurol Sci 1998,158(2):154-163. | Maher JK and Kronenberg M.. Curr Opin Immunol 1997, 9(4):456-461 | Blumberg RS et al. Immunol Rev 1995, 147:5-29. | Salamone MC et al. Dis Markers 1990, 8(5):275-281 | |
详情介绍: | Function Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. Cellular_Location Cell membrane; Single-pass type I membrane protein. Endosome membrane. Note=Subject to intracellular trafficking between the cell membrane and endosomes. Localizes to cell surface lipid rafts Tissue_Location Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. | ||
别名: | T-cell surface glycoprotein CD1a, T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen, CD1a, CD1A | 说明书: |
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