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品牌： | Leading Biology | 货号： | LM14925 |
规格： | 20 μg | 产品官网链接： | |
产品分类： | 单克隆抗体 | 研究领域： | |
产品概述： | Recognizes a protein of 140kDa, which is identified as the complement receptor 2 (CR2)/CD21. Its epitope is located in 5-8 short consensus repeats (SCRs). This MAb is highly specific to CR2 and shows no cross-reaction with CR1. This protein is expressed strongly on mature B cells, follicular dendritic cells and weakly on immature thymocytes and T lymphocytes. In B-cell ontogeny, CD21 appears after the pre-B-stage, is maintained during peripheral B-cell development and is lost upon terminal differentiation into plasma cells. CD21 expression is also gradually lost after stimulation of B cells in vitro. CD21 functions as receptor for C3d, C3dg and iC3b Complement components, for EBV and for IFNalpha. CD21 binds to CD23 and associates with CD19, CD81 and Leu13 to form a large signal-transduction complex involved in B cell activation. MAb FR5A10 can be used for EBV receptor studies, interactions between B and T cells especially through CD23, human complement receptor (CR2) studies and IFN-alpha receptor studies. | 来源： | Mouse |
靶点/蛋白质： | 特异性： | Human | |
存储温度： | Store at 2 to 8°C.Antibody is stable for 24 months. | 存储溶液： | |
应用： | 参考文献： | Schlossman SF et al. eds Leukocyte Typing V, p516-522, Oxford University Press, Oxford, 1995. | Aubry JP et al.In Schlossman SF et al eds. Leukocyte Typing V, p535-536, Oxford University Press, Oxford, 1995 | |
详情介绍： | Function Receptor for complement C3Dd, for the Epstein-Barr virus on human B-cells and T-cells and for HNRPU. Participates in B lymphocytes activation. Cellular_Location Membrane; Single-pass type I membrane protein Tissue_Location Mature B-lymphocytes, T-lymphocytes, pharyngeal epithelial cells, astrocytes and follicular dendritic cells of the spleen | ||
别名： | Complement receptor type 2, Cr2, Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor, CD21, CR2, C3DR | 说明书： | |
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高额赔付
8000万＋
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