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anti- AXL antibody
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市场价￥1,750.00好评率100%(0)条评论
商城价 登录后可查看价格 - 货号 FNab00754
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FineTest
- CAS号 见包装
- 规格/包装 100ug
- 售卖单位 管
- 储存条件 -20度 12个月
- 现货状态 三个工作日
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anti- AXL antibody抗体具有高亲合力和高特异性深受国外市场认可；菲恩生物专注于免疫学、细胞生物学、肿瘤、神经生物学等领域。
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产品介绍
| 品名 | anti- AXL antibody | |
| 货号 | FNab00754 | |
| 规格 | 100µg | |
| 纯化方法 | Immunogen affinity purified | |
| 纯度 | ≥95% as determined by SDS-PAGE | |
| 宿主 | Rabbit | |
| 亚型 | IgG | |
| 存储 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | |
| 背景介绍 | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors(TLRs)-mediated innate immune response. (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope(PubMed:22156524, PubMed:22673088, PubMed:25277499, PubMed:21501828). Acts as a receptor for ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope(PubMed:17005688). | |
| 免疫原 | AXL receptor tyrosine kinase | |
| 别称 | AXL|AXL oncogene|AXL receptor tyrosine kinase|JTK11|UFO | |
| 分子量 | 140 kDa | |
| Uniprot ID | P30530 | |
| 适用种属 | Human, Mouse, Rat | |
| 验证应用 | ELISA, WB, IP, FC | |
| 建议稀释比例 | WB: 1:500-1:3000; IP: 1:500-1:2000 | |
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HepG2 cells were subjected to SDS PAGE followed by western blot with FNab00754(AXL antibody) at dilution of 1:500 | |
| 注意事项 | anti- AXL antibody抗体仅供科研使用 | |
| 产品链接 | https://www.fn-test.cn/product/FNab00754/ | |
菲恩生物简介
武汉菲恩生物科技有限公司(Wuhan Fine Biotech Co., Ltd.)面向国际市场专业研发、生产和销售ELISA试剂盒、抗体、重组蛋白及相关试剂。产品在免疫学、信号转导、代谢、神经科学等领域内都有最前沿科学文献发表，被国内外多所大学、研究机构和药学平台使用并发表文献多达1000多次。产品主销国外市场，在40多个国家设有代理商，全球合作商达100余个。武汉菲恩生物科技有限公司凭借优异的产品和完善的服务体系现已受到广大国内外用户的青睐和认可。FineTest®科研好帮手，专业生产商
FineTest®品牌优势
1、产品优势：产品具有高特异性、回收率高、线性好、变异系数低、稳定性好；
2、质量保证：产品质量稳定，每批次产品必须通过QA、QC检测才可出库；
3、实力强大：ISO9001:2015认证，标准实验室、研发中心，动物房，高新技术企业；
4、技术支持：技术部5*8小时技术问题及时解答；
5、服务周到：发货及时，三个工作日顺丰快递；售后无忧，24小时快速响应。
研发、生产科研产品：
ELISA试剂盒主要指标：
1、细胞因子：IL、Selectin、CSF、TNF、IF、TGF、chemokine、CAM、IGF、CR等；
2、心肌梗塞：cTn，MYO，CRP等；
3、内分泌：TH、Pg、Testosterone、GH、Cytokine receptor、Endothelin、COR、BGP、PRL、ACTH、FSH、Estradiol等；
4、肝纤维化：HA、MMP、LN等；
5、肿瘤标志物：TNF、TNFSF10、TNFRSF1A等；
6、特种蛋白：Ig、CRP、ALB、FE、TRF等。
抗体：兔多抗、鼠单抗种类丰富，一抗1万余种，二抗100多种；
重组蛋白：多项发明专利，原核表达系统稳定表达蛋白1000余种。
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