产品名：重组人白介素1β/ Recombinant Human IL-1β

产品号： 产品信息： 白细胞介素-1β，简称白介素1β(IL-1β)，是一种细胞因子，属于白细胞介素1家族。它是由活化的巨噬细胞所产生的前体经Caspase 1 (CASP1/ICE)酶切生成。IL-1β作为一个重要的炎症应答中间因子，能够参与免疫反应中的多种细胞活动，包括细胞增殖、分化和凋亡。在中枢神经系统中由IL-1β诱导产生的cyclooxygenase-2 (PTGS2/COX2)被证明与炎症疼痛过敏有关。

别名: Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF) 英文描述: IL-1β is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and IL-1β bind to the same receptor and have similar, if not identical, biological properties. These cytokines have a broad range of activities including the stimulation of thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant Human IL-1β is a 17.3 kDa protein containing 153 amino acid residues.

氨基酸序列: APVRSLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKEKNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYISTSQAENMPVFLGGTKGGQDITDFTMQFVSS

表达宿主来源:E.coli

保存条件：4℃保存6个月，-20℃保存一年或-80℃长期保存。

纯度&内毒素： Greater than 95% by SDS-PAGE gel and HPLC analyses. Endotoxin Level<0.5EU/μg