产品名：重组人白介素15（IL-15）

产品号：LT0123

产品信息：

白介素15是白介素2细胞因子家族成员之一，通过Yc受体亚单位发挥生物学功能。目前已有多项针对肿瘤和血液肿瘤的治疗进入临床。白介素2与白介素15都参与早期T细胞增殖与激活。白介素15的抗肿瘤活性还来源于通过非抗原特异性方式直接激活CD8⁺ 效应T细胞。白介素15针对免疫细胞治疗的研究已经进入Ⅰ期临床。

别名: IL-T

英文描述:

IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2.  IL-15 exerts its biological activities primarily on T cells.  It is also essential in the development, survival and activation of NK cells.  Increased expression of IL-15 has been linked to with rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I.  Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells.  Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues.

氨基酸序列:

MNWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS

来源:

E.coli

纯度&内毒素：

Greater than 95% by SDS-PAGE

gel and HPLC analyses.

Endotoxin Level<0.5EU/μg

生物活性:
The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10⁶ units/mg.